SCHEMBL8065883

SCHEMBL8065883

O=C(C=Cc1ccc(Cl)cc1)Nc1ccc(Cl)cc1C(=O)O

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 3/20 0.75
EGFR P00533 2/20 0.64
KDM4E B2RXH2 3/20 0.61
ALDH1A1 P00352 2/20 0.61
HPGD P15428 2/20 0.61
TP53 P04637 1/20 0.61
MEN1 O00255 1/20 0.61
NPC1 O15118 1/20 0.61
RAB9A P51151 1/20 0.61
KMT2A Q03164 1/20 0.61
SMN1; SMN2 Q16637 1/20 0.61
NPSR1 Q6W5P4 1/20 0.61
TRPM2 O94759 3/20 0.60
POLB P06746 1/20 0.59
CTDSP1 Q9GZU7 1/20 0.58
KCNK2 O95069 1/20 0.58
HSD17B10 Q99714 1/20 0.57
MAPT P10636 1/20 0.57
MMP1 P03956 2/20 0.57
MMP2 P08253 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8065880 1.00 TRPA1 (0.75) TRPA1EGFRKDM4EALDH1A1HPGD
SCHEMBL8060454 0.93 EGFR (0.75) TRPA1EGFRKDM4EALDH1A1HPGD
SCHEMBL8060457 0.93 EGFR (0.75) TRPA1EGFRKDM4EALDH1A1HPGD
SCHEMBL8064019 0.92 TP53 (0.74) TRPA1EGFRKDM4EALDH1A1HPGD
SCHEMBL8064022 0.92 TP53 (0.74) TRPA1EGFRKDM4EALDH1A1HPGD
SCHEMBL8065974 0.92 TRPA1 (0.68) TRPA1EGFRKDM4EALDH1A1HPGD
SCHEMBL8059600 0.92 TRPA1 (0.68) TRPA1EGFRKDM4EALDH1A1HPGD
SCHEMBL8059603 0.92 TRPA1 (0.68) TRPA1EGFRKDM4EALDH1A1HPGD
SCHEMBL8065971 0.92 TRPA1 (0.68) TRPA1EGFRKDM4EALDH1A1HPGD
SCHEMBL420925 0.91 TRPM2 (0.74) TRPA1EGFRKDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6127392-A A MUSCLE RELAXANT FOR TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION; INOTROPIC AGENT AMERICAN HOME PRODUCTS CORPORATION (US) 2000-10-03 US disclosed
US-6046239-A USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE AMERICAN HOME PRODUCTS CORPORATION (US) 2000-04-04 US disclosed