Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8435181 | 1.00 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL3266233 | 1.00 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL7926706 | 1.00 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL532723 | 1.00 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL711064 | 1.00 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL9145494 | 1.00 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL9146197 | 1.00 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL3261 | 1.00 | — | — | |
| Bicarbonate SCHEMBL1331961 | 1.00 | — | — | |
| Bicarbonate SCHEMBL1537736 | 1.00 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124031-A | THERMOPLASTIC POLYESTER LAYER A MADE FROM AN AROMATIC DIACID AND AN ALIPHATIC GLYCOL AND THETA-TYPE ALUMINUM OXIDE PARTICLES, AND AT LEAST ONE OTHER THERMOPLASTIC POLYESTER LAMINATED TO LAYER A; MAGNETIC RECORDING MEDIA BASE FILM | TORAY INDUSTRIES, INC. (JP) | 2000-09-26 | — | — | US | disclosed |
| US-5670236-A | PARTICLES OF SURFACE-TREATED CALCIUM CARBONATE AND ALUMINA; WEAR RESISTANCE, DUSTLESS | DIAFOIL HOECHST COMPANY, LTD. (JP) | 1997-09-23 | — | — | US | disclosed |
| US-4550130-A | POLYOLEFIN MODIFIED WITH UNSATURATED CARBOXYLIC ACID, AND AMINE, EPOXY, AND/OR ISOCYANATE WITH REINFORCEMENT | MITSUBISHI RAYON CO., LTD. (JP) | 1985-10-29 | — | — | US | disclosed |