SCHEMBL8059958

SCHEMBL8059958

Cc1c(OCC(F)(F)F)ccnc1CSc1nc2cc(-n3ccnc3)c(F)cc2[nH]1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.61
CYP1A2 P05177 2/20 0.61
CYP3A4 P08684 2/20 0.61
CYP2D6 P10635 2/20 0.61
CYP2C9 P11712 2/20 0.61
CYP2C19 P33261 2/20 0.61
RAB9A P51151 2/20 0.61
OPRL1 P41146 10/20 0.40
MAPT P10636 3/20 0.39
ATP1A1 P05023 3/20 0.39
ATP1B1 P05026 3/20 0.39
ATP1A3 P13637 3/20 0.39
ATP1B2 P14415 3/20 0.39
ATP4A P20648 3/20 0.39
ATP1A2 P50993 3/20 0.39
ATP4B P51164 3/20 0.39
ATP1B3 P54709 3/20 0.39
FXYD2 P54710 3/20 0.39
ATP1A4 Q13733 3/20 0.39
WDR5 P61964 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8071118 0.90 NPC1 (0.47) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8070664 0.89 CYP2C9 (0.46) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8070793 0.85 OPRL1 (0.44) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8070545 0.84 NPC1 (0.62) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8069281 0.84 NPC1 (0.61) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8071088 0.82 NPC1 (0.39) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8071182 0.81 OPRL1 (0.44) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8133110 0.80 ATP4A (0.39) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8929842 0.80 CYP2D6 (0.51) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL29527281 0.80 RAB9A (0.76) NPC1CYP1A2CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6051570-A ANTIULCER AGENTS DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-04-18 US claimed
EP-0983263-A1 NOVEL BENZIMIDAZOLE DERIVATIVES AS ANTIULCER AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-03-08 EP claimed
WO-1998054172-A1 NOVEL BENZIMIDAZOLE DERIVATIVES AS ANTIULCER AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S RESEARCH FOUNDATION (IN) 1998-12-03 WO claimed
US-6051570-A ANTIULCER AGENTS DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-04-18 US disclosed
EP-0983263-A1 NOVEL BENZIMIDAZOLE DERIVATIVES AS ANTIULCER AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-03-08 EP disclosed
WO-1998054172-A1 NOVEL BENZIMIDAZOLE DERIVATIVES AS ANTIULCER AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S RESEARCH FOUNDATION (IN) 1998-12-03 WO disclosed