Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 7/20 | 0.59 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.55 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6534730 | 0.81 | BRS3 (0.52) | BRS3AGTR1AGTR2 | |
| SCHEMBL9196627 | 0.78 | AGTR1 (0.55) | BRS3AGTR1AGTR2 | |
| SCHEMBL9304542 | 0.78 | BRS3 (0.56) | BRS3AGTR1AGTR2 | |
| SCHEMBL9200834 | 0.78 | AGTR1 (0.53) | BRS3AGTR1AGTR2 | |
| SCHEMBL1227544 | 0.77 | BRS3 (0.55) | BRS3AGTR1AGTR2 | |
| SCHEMBL9428665 | 0.76 | AGTR1 (0.55) | BRS3AGTR1AGTR2 | |
| SCHEMBL9552678 | 0.76 | BRS3 (0.57) | BRS3AGTR1AGTR2 | |
| SCHEMBL9510826 | 0.76 | BRS3 (0.55) | BRS3AGTR1AGTR2 | |
| SCHEMBL9452733 | 0.76 | BRS3 (0.56) | BRS3AGTR1AGTR2 | |
| SCHEMBL3906504 | 0.76 | BRS3 (0.70) | BRS3AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962500-A | HYPOSENSITVE AGENT | MERCK SHARP & DOHME CORP. | 1999-10-05 | — | — | US | claimed |
| EP-0533840-A1 | TREATMENT OF CHRONIC RENAL FAILURE WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS. | DU PONT (US) | 1993-03-31 | — | — | EP | claimed |
| EP-1019048-A1 | USE OF AN ANGIOTENSIN II RECEPTOR ANTAGONIST FOR THE PREPARATION OF DRUGS TO INCREASE THE SURVIVAL RATE OF RENAL TRANSPLANT PATIENTS | Merck Sharp Dohme (Italia) S.P.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| US-5962500-A | HYPOSENSITVE AGENT | MERCK SHARP & DOHME CORP. | 1999-10-05 | — | — | US | disclosed |
| WO-1999016437-A1 | USE OF AN ANGIOTENSIN II RECEPTOR ANTAGONIST FOR THE PREPARATION OF DRUGS TO INCREASE THE SURVIVAL RATE OF RENAL TRANSPLANT PATIENTS | MERCK SHARP DOHME (ITALIA) S.P.A. (IT) | 1999-04-08 | — | — | WO | disclosed |
| US-5663186-A | TREATING ATHEROSCLEROSIS AND REDUCING CHOLESTEROL ALONE OR IN CONJUCTION WITH THE TREATMENT OF HYPERTENSION USING A MIXTURE OF LOSARTAN, SIMVASTATIN AND ENALPRIL | MERCK & CO., INC. (US) | 1997-09-02 | — | — | US | disclosed |