Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1571230 | 0.90 | PTGS2 (0.54) | PTGS2ALDH1A1CYP1A2GAACYP2C19 | |
| SCHEMBL1784315 | 0.84 | ALDH1A1 (0.63) | PTGS2ALDH1A1CYP1A2GAACYP2C19 | |
| SCHEMBL839776 | 0.83 | PTGS2 (0.83) | PTGS2ALDH1A1CYP1A2CYP2C19POLB | |
| SCHEMBL8625852 | 0.81 | PTGDR2 (0.50) | ALDH1A1CYP2C19SMN1; SMN2ALOX5KMT2A | |
| SCHEMBL15517693 | 0.81 | PTGS2 (0.51) | PTGS2ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6843426 | 0.81 | PTGS2 (0.51) | PTGS2ALDH1A1CYP1A2GAACYP2C19 | |
| SCHEMBL2684045 | 0.80 | PTGS2 (0.48) | PTGS2ALDH1A1CYP1A2GAACYP2C19 | |
| SCHEMBL3971667 | 0.80 | PTGS2 (0.77) | PTGS2ALDH1A1CYP1A2CYP2C19POLB | |
| SCHEMBL7712725 | 0.80 | PTGS2 (0.50) | PTGS2ALDH1A1CYP1A2GAACYP2C19 | |
| SCHEMBL18721152 | 0.80 | PTGS2 (0.57) | PTGS2ALDH1A1CYP1A2GAACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6072046-A | SELECTIVELY FORM TRIPLEXES WITH A COMPLEMENTARY TARGET SEQUENCE IN DOUBLE-STRANDED DNA AND EFFICIENTLY CROSSLINK WITH BOTH STRANDS; THERAPEUTICS, DIAGNOSTICS, AND GENETIC PROBES | EPOCH PHARMACEUTICALS, INC. (US) | 2000-06-06 | — | — | US | disclosed |