SCHEMBL806032

SCHEMBL806032

CCOC(=O)c1cc(Cl)cc(-c2cccc(OC3=CC(C)C(F)C=C3)c2)n1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.40
THRB P10828 1/20 0.40
CYP1A2 P05177 2/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
GABRA2 P47869 2/20 0.37
GABRB2 P47870 2/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
NPSR1 Q6W5P4 2/20 0.35
ALDH1A1 P00352 1/20 0.35
LMNA P02545 1/20 0.35
ALOX12 P18054 1/20 0.35
HTT P42858 1/20 0.35
KDM4E B2RXH2 3/20 0.35
TRPM8 Q7Z2W7 1/20 0.34
SCN9A Q15858 1/20 0.34
FAAH O00519 3/20 0.34
HPGD P15428 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
P2RY12 Q9H244 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL787316 0.78 SCN9A (0.54) MAPTTHRBCYP1A2CYP2C9CYP2C19
SCHEMBL1200252 0.73 GABRA2 (0.55) MAPTCYP1A2GABRA2GABRB2L3MBTL1
SCHEMBL3327719 0.65 CYP1A2 (0.61) MAPTCYP1A2GABRA2GABRB2L3MBTL1
SCHEMBL30925060 0.63 MAPT (0.56) MAPTTHRBCYP1A2GABRA2GABRB2
SCHEMBL29214329 0.63 MAPT (0.56) MAPTTHRBCYP1A2GABRA2GABRB2
SCHEMBL4305339 0.63 L3MBTL1 (0.46) MAPTCYP1A2GABRA2GABRB2L3MBTL1
SCHEMBL25275643 0.62 PIK3C3 (0.44) GABRA2GABRB2
SCHEMBL31127029 0.61 CYP1A2 (0.51) MAPTCYP1A2GABRA2GABRB2L3MBTL1
SCHEMBL787591 0.61 CYP1A2 (0.51) MAPTCYP1A2GABRA2GABRB2L3MBTL1
SCHEMBL2823510 0.61 CYP1A2 (0.51) MAPTTHRBCYP1A2GABRA2GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012035421-A2 PYRIDINE COMPOUNDS AND THE USES THEREOF PURDUE PHARMA L.P. (US) 2012-03-22 WO disclosed