Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 17/20 | 0.78 |
| ▸ | ADRA1A | P35348 | 17/20 | 0.78 |
| ▸ | ADRA1B | P35368 | 17/20 | 0.78 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060367 | 0.92 | ADRA1D (0.74) | ADRA1DADRA1AADRA1BCA12CA9 | |
| SCHEMBL8060389 | 0.91 | ADRA1D (0.64) | ADRA1DADRA1AADRA1B | |
| SCHEMBL8674154 | 0.88 | ADRA1D (1.00) | ADRA1DADRA1AADRA1B | |
| SCHEMBL8672562 | 0.81 | ADRA1D (1.00) | ADRA1DADRA1AADRA1B | |
| SCHEMBL8674153 | 0.78 | ADRA1D (0.82) | ADRA1DADRA1AADRA1B | |
| SCHEMBL8047927 | 0.78 | OPRM1 (0.52) | ADRA1DADRA1AADRA1B | |
| SCHEMBL8670877 | 0.78 | ADRA1D (1.00) | ADRA1DADRA1AADRA1B | |
| SCHEMBL8048061 | 0.78 | ADRA1D (0.49) | ADRA1DADRA1AADRA1BCA12CA9 | |
| SCHEMBL8670191 | 0.77 | ADRA1D (1.00) | ADRA1DADRA1AADRA1B | |
| SCHEMBL8666853 | 0.77 | ADRA1D (1.00) | ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996025934-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-08-29 | — | — | WO | claimed |
| US-6096763-A | ADMINISTERING TO THE PATIENTS A2-OXO-1-BENZIMIDAZOLINYL)PIPERIDIN-1-YL)ALKYL)-1,2BENZISOTHIA ZOL-3-(2H)-ONE DERIVATIVE AS ALPHA-1A ADRENERGIC RECEPTOR ANTAGONIST | MERCK & CO., INC. (US) | 2000-08-01 | — | — | US | disclosed |
| US-5952351-A | DERIVATIVES OF 1,1,3-TRIOXO-2-((2-OXOBENZIMIDAZOLIN- OR BENZOXAZOLIN-2-YL)-PIPERIDIN-4,1-YLENE-)-1,2-BENZISOTHIAZOLE; TREATMENT OF BENIGN PROSTATIC HYPERPLASIA; SELECTIVE RELAXATION OF SMOOTH MUSCLE WITHOUT INDUCING HYPOTENSION | MERCK & CO., INC. (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0812196-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1998-05-20 | — | — | EP | disclosed |
| EP-0812196-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1997-12-17 | — | — | EP | disclosed |
| WO-1996025934-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-08-29 | — | — | WO | disclosed |