SCHEMBL8060558

SCHEMBL8060558

c1cc([C]2CCCCC2)no1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 1/20 0.37
NPC1 O15118 3/20 0.33
RAB9A P51151 3/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP19A1 P11511 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
KDM4E B2RXH2 2/20 0.33
ALDH1A1 P00352 1/20 0.32
TP53 P04637 1/20 0.32
ALOX15 P16050 1/20 0.32
TSHR P16473 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HSD17B10 Q99714 1/20 0.32
MDM2 Q00987 1/20 0.31
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21807785 0.98 CHRM1 (0.38) CHRM1NPC1RAB9ACYP1A2CYP2D6
SCHEMBL22806989 0.93
SCHEMBL4472253 0.88
SCHEMBL3082762 0.74 NPC1 (0.42) CHRM1NPC1RAB9ACYP1A2CYP2D6
SCHEMBL4059081 0.67 CYP1A2 (0.57) CHRM1NPC1RAB9ACYP1A2CYP2D6
Methoxymethane SCHEMBL27908243 0.65 RAB9A (0.50) CHRM1NPC1RAB9ACYP1A2CYP2D6
SCHEMBL27515250 0.64 CHRM1 (0.34) CHRM1NPC1RAB9ACYP1A2CYP2D6
SCHEMBL4059082 0.64 MDM2 (0.41) CHRM1NPC1RAB9ACYP1A2CYP2D6
SCHEMBL28934089 0.64
SCHEMBL27631688 0.63 NPC1 (0.33) CHRM1NPC1RAB9ACYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6048885-A FUNGICIDES SHIONOGI & CO., LTD. (JP) 2000-04-11 US disclosed