Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | METAP2 | P50579 | 2/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3306672 | 0.84 | METAP2 (0.47) | HTR2AMETAP2PLAUNCF1ALDH1A1 | |
| SCHEMBL4394002 | 0.84 | METAP2 (0.57) | METAP2PLAUNCF1ALDH1A1CYP1A2 | |
| SCHEMBL18131613 | 0.83 | METAP2 (0.53) | METAP2PLAUNCF1ALDH1A1CYP1A2 | |
| SCHEMBL2484187 | 0.81 | METAP2 (0.55) | METAP2PLAUNCF1ALDH1A1CYP1A2 | |
| SCHEMBL4393939 | 0.81 | METAP2 (0.53) | METAP2PLAUNCF1ALDH1A1CYP1A2 | |
| SCHEMBL8236564 | 0.80 | METAP2 (0.52) | METAP2PLAUNCF1ALDH1A1CYP1A2 | |
| SCHEMBL1160443 | 0.79 | METAP2 (0.51) | METAP2PLAUNCF1ALDH1A1CYP1A2 | |
| SCHEMBL7923339 | 0.78 | METAP2 (0.50) | METAP2PLAUNCF1ALDH1A1CYP1A2 | |
| SCHEMBL4792326 | 0.78 | PLAU (0.55) | METAP2PLAUNCF1ALDH1A1CYP1A2 | |
| SCHEMBL1101005 | 0.78 | PARP1 (0.58) | METAP2PLAUNCF1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1014960-A1 | USE OF A SPECIFIC ANTAGONIST OF 5HT2 RECEPTORS FOR PREPARING MEDICINES USEFUL FOR TREATING SLEEP-DISORDERED BREATHING | SANOFI-SYNTHELABO (FR) | 2000-07-05 | — | — | EP | claimed |
| WO-1999000119-A1 | USE OF A SPECIFIC ANTAGONIST OF 5HT2 RECEPTORS FOR PREPARING MEDICINES USEFUL FOR TREATING SLEEP-DISORDERED BREATHING | SANOFI-SYNTHELABO (FR) | 1999-01-07 | — | — | WO | claimed |