Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 6/20 | 1.00 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 5/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.68 |
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | TP53 | P04637 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.68 |
| ▸ | HPGDS | O60760 | 1/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060572 | 1.00 | TRPA1 (1.00) | TRPA1TRPM8MEN1KMT2ANPC1 | |
| SCHEMBL2779873 | 0.90 | TRPA1 (0.82) | TRPA1TRPM8MEN1KMT2ANPC1 | |
| SCHEMBL2779875 | 0.90 | TRPA1 (0.82) | TRPA1TRPM8MEN1KMT2ANPC1 | |
| SCHEMBL11666646 | 0.90 | TRPA1 (0.82) | TRPA1TRPM8MEN1KMT2ANPC1 | |
| SCHEMBL11666647 | 0.90 | TRPA1 (0.82) | TRPA1TRPM8MEN1KMT2ANPC1 | |
| SCHEMBL8641484 | 0.88 | TRPA1 (0.79) | TRPA1TRPM8MEN1KMT2ANPC1 | |
| SCHEMBL8641477 | 0.88 | TRPA1 (0.79) | TRPA1TRPM8MEN1KMT2ANPC1 | |
| SCHEMBL2779698 | 0.88 | TRPA1 (0.78) | TRPA1TRPM8MEN1KMT2ANPC1 | |
| SCHEMBL2779695 | 0.88 | TRPA1 (0.78) | TRPA1TRPM8MEN1KMT2ANPC1 | |
| SCHEMBL14801976 | 0.87 | TRPA1 (0.76) | TRPA1TRPM8MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127392-A | A MUSCLE RELAXANT FOR TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION; INOTROPIC AGENT | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-10-03 | — | — | US | disclosed |
| US-6046239-A | USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-04-04 | — | — | US | disclosed |