Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | PKLR | P30613 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.56 |
| ▸ | MMP3 | P08254 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471529 | 0.80 | PKM (0.73) | PKMNPC1PKLRRAB9ASMN1; SMN2 | |
| SCHEMBL28079047 | 0.80 | PKM (0.63) | PKMNPC1PKLRRAB9ASMN1; SMN2 | |
| SCHEMBL3010882 | 0.80 | PKM (0.70) | PKMNPC1PKLRRAB9ASMN1; SMN2 | |
| SCHEMBL4799931 | 0.80 | PKM (0.78) | PKMNPC1PKLRRAB9ASMN1; SMN2 | |
| SCHEMBL23178943 | 0.79 | PKM (0.75) | PKMNPC1PKLRRAB9ASMN1; SMN2 | |
| SCHEMBL8200209 | 0.78 | PKM (0.60) | PKMNPC1PKLRRAB9ASMN1; SMN2 | |
| SCHEMBL31315853 | 0.78 | PKM (1.00) | PKMNPC1PKLRRAB9ASMN1; SMN2 | |
| SCHEMBL1722721 | 0.78 | PKM (1.00) | PKMNPC1PKLRRAB9ASMN1; SMN2 | |
| SCHEMBL4541877 | 0.77 | PKM (0.56) | PKMNPC1PKLRRAB9ASMN1; SMN2 | |
| SCHEMBL7510989 | 0.77 | KMT2A (0.82) | PKMALDH1A1HTTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |