Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | PKLR | P30613 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | CCR6 | P51684 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28831518 | 0.83 | SMN1; SMN2 (0.47) | PKMNPC1PKLRRAB9ASMN1; SMN2 | |
| SCHEMBL28078925 | 0.81 | KMT2A (0.60) | NPC1ALDH1A1TSHRLMNAHPGD | |
| SCHEMBL8060759 | 0.80 | PKM (0.64) | PKMNPC1PKLRRAB9ASMN1; SMN2 | |
| SCHEMBL23178943 | 0.80 | PKM (0.75) | PKMNPC1PKLRRAB9ASMN1; SMN2 | |
| SCHEMBL1722721 | 0.79 | PKM (1.00) | PKMNPC1PKLRRAB9ASMN1; SMN2 | |
| SCHEMBL31315853 | 0.79 | PKM (1.00) | PKMNPC1PKLRRAB9ASMN1; SMN2 | |
| SCHEMBL7471529 | 0.79 | PKM (0.73) | PKMNPC1PKLRRAB9ASMN1; SMN2 | |
| SCHEMBL8200209 | 0.77 | PKM (0.60) | PKMNPC1PKLRRAB9ASMN1; SMN2 | |
| SCHEMBL8207642 | 0.77 | PKM (0.60) | PKMNPC1PKLRRAB9ASMN1; SMN2 | |
| SCHEMBL22032745 | 0.76 | SMN1; SMN2 (0.60) | PKMNPC1PKLRRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105873913-A | Therapeutics targeting truncated adenomatous polyposis coli (APC) proteins | 得克萨斯系统大学评议会 | 2016-08-17 | — | — | CN | disclosed |