SCHEMBL8060767

SCHEMBL8060767

CC(C)[C@H](N)C(=O)N(C(=O)OC(C)(C)C)[C@H](C)c1nc2ccccc2s1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.53
PAX8 Q06710 1/20 0.47
RAB9A P51151 2/20 0.42
LOXL2 Q9Y4K0 1/20 0.41
TSHR P16473 3/20 0.41
ALOX15 P16050 2/20 0.41
CASP1 P29466 1/20 0.39
HPGD P15428 3/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
HIF1A Q16665 1/20 0.38
HSD17B10 Q99714 1/20 0.38
GAA P10253 1/20 0.37
MAPK1 P28482 1/20 0.37
ALDH1A1 P00352 4/20 0.37
LMNA P02545 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
APEX1 P27695 1/20 0.36
PKM P14618 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8071496 0.85 PPARA (0.40) ALOX5RAB9AGAAALDH1A1LMNA
SCHEMBL8897007 0.80 ALOX5 (0.51) ALOX5ALOX15CYP1A2GAALMNA
SCHEMBL8076380 0.79 HTT (0.40) PAX8TSHRCASP1GAAMAPK1
SCHEMBL8897895 0.77 ALOX5 (0.39) ALOX5PAX8ALOX15HPGDHSD17B10
SCHEMBL4159545 0.75 ALOX5 (0.50) ALOX5PAX8RAB9ALOXL2TSHR
SCHEMBL6910037 0.74 ALOX5 (0.45) ALOX5RAB9ALOXL2TSHRALOX15
SCHEMBL6912020 0.73 PKM (0.45) ALOX5RAB9ALOXL2TSHRALOX15
SCHEMBL726362 0.72
SCHEMBL6914078 0.72 TSHR (0.43) ALOX5RAB9ALOXL2TSHRALOX15
SCHEMBL7473224 0.72 TSHR (0.43) ALOX5RAB9ALOXL2TSHRALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0775696-B1 AMINO ACID AMIDE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AGROHORTICULTURAL FUNGICIDE, AND FUNGICIDAL METHOD KUMIAI CHEMICAL INDUSTRY CO (JP) 2000-07-19 EP disclosed
EP-0775696-A1 AMINO ACID AMIDE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AGROHORTICULTURAL FUNGICIDE, AND FUNGICIDAL METHOD KumaiI Chemical Industry Co., Ltd. (JP) 1997-05-28 EP disclosed