Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 15/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 7/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.32 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7786693 | 1.00 | SPHK1 (0.39) | SPHK1SPHK2S1PR1S1PR4S1PR5 | |
| SCHEMBL8062250 | 1.00 | SPHK1 (0.39) | SPHK1SPHK2S1PR1S1PR4S1PR5 | |
| SCHEMBL7930556 | 0.80 | SPHK1 (0.33) | SPHK1SPHK2S1PR1S1PR4S1PR5 | |
| SCHEMBL8462721 | 0.80 | SPHK1 (0.33) | SPHK1SPHK2S1PR1S1PR4S1PR5 | |
| SCHEMBL7796703 | 0.80 | SPHK1 (0.46) | SPHK1SPHK2 | |
| SCHEMBL5722618 | 0.77 | HTR1D (0.32) | — | |
| SCHEMBL6158197 | 0.73 | SPHK1 (0.35) | SPHK1SPHK2 | |
| SCHEMBL9618524 | 0.72 | S1PR1 (0.39) | SPHK1SPHK2S1PR1S1PR4S1PR5 | |
| SCHEMBL7928544 | 0.71 | RARB (0.42) | S1PR1S1PR4S1PR5S1PR2S1PR3 | |
| SCHEMBL5722804 | 0.71 | RAB9A (0.39) | S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159392-A | 5,7-difluoro-1,2,3,4-tetrahydronaphthalene derivatives and their use thereof in liquid crystal mixtures | AVENTIS RESEARCH & TECHNOLOGIES GMBH & CO. KG (DE) | 2000-12-12 | — | — | US | disclosed |