Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 8/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27510568 | 1.00 | ROCK2 (0.39) | ROCK2ROCK1BACE1PSMB8PSMB5 | |
| SCHEMBL7139827 | 0.95 | ROCK2 (0.39) | ROCK2ROCK1BACE1PSMB8PSMB5 | |
| SCHEMBL7139835 | 0.95 | ROCK2 (0.39) | ROCK2ROCK1BACE1PSMB8PSMB5 | |
| SCHEMBL8051508 | 0.92 | ROCK2 (0.43) | ROCK2ROCK1MAPTTDP1NPSR1 | |
| SCHEMBL8063417 | 0.91 | ROCK2 (0.43) | ROCK2ROCK1PSMB8PSMB5MEN1 | |
| SCHEMBL8051485 | 0.90 | ROCK2 (0.39) | ROCK2ROCK1PSMB8PSMB5MAPT | |
| SCHEMBL8062348 | 0.89 | ROCK2 (0.41) | ROCK2ROCK1PSMB8PSMB5MAPT | |
| SCHEMBL8063451 | 0.89 | ROCK2 (0.37) | ROCK2ROCK1BACE1PSMB8PSMB5 | |
| SCHEMBL8063461 | 0.86 | ROCK2 (0.38) | ROCK2ROCK1BACE1PSMB8PSMB5 | |
| SCHEMBL8063457 | 0.86 | ROCK2 (0.38) | ROCK2ROCK1BACE1PSMB8PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100282-A | Thiazole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2000-08-08 | — | — | US | disclosed |
| CN-1224718-A | Thiazole derivatives | HOFFMANN LA ROCHE (CH) | 1999-08-04 | — | — | CN | disclosed |