Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 4/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.34 |
| ▸ | ITGAV | P06756 | 2/20 | 0.34 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.34 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.34 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.34 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.34 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.34 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.34 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.34 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.34 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.34 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.34 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139835 | 0.93 | ROCK2 (0.39) | ROCK2ROCK1PSMB8PSMB5BACE1 | |
| SCHEMBL7139827 | 0.93 | ROCK2 (0.39) | ROCK2ROCK1PSMB8PSMB5BACE1 | |
| SCHEMBL8063448 | 0.89 | ROCK2 (0.39) | ROCK2ROCK1PSMB8PSMB5BACE1 | |
| SCHEMBL27510568 | 0.89 | ROCK2 (0.39) | ROCK2ROCK1PSMB8PSMB5BACE1 | |
| SCHEMBL8063417 | 0.89 | ROCK2 (0.43) | ROCK2ROCK1PSMB8PSMB5SMN1; SMN2 | |
| SCHEMBL8062348 | 0.88 | ROCK2 (0.41) | ROCK2ROCK1PSMB8PSMB5SMN1; SMN2 | |
| SCHEMBL8051508 | 0.86 | ROCK2 (0.43) | ROCK2ROCK1SMN1; SMN2ITGB3ITGAV | |
| SCHEMBL8051485 | 0.85 | ROCK2 (0.39) | ROCK2ROCK1PSMB8PSMB5SMN1; SMN2 | |
| SCHEMBL8063461 | 0.84 | ROCK2 (0.38) | ROCK2ROCK1PSMB8PSMB5SMN1; SMN2 | |
| SCHEMBL8063457 | 0.84 | ROCK2 (0.38) | ROCK2ROCK1PSMB8PSMB5SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100282-A | Thiazole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2000-08-08 | — | — | US | disclosed |