Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | ACP3 | P15309 | 3/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | CASR | P41180 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5054565 | 0.86 | ACP3 (0.44) | ACP3KMT2AMEN1 | |
| SCHEMBL8061463 | 0.85 | MEN1 (0.46) | ATMKMT2ASMN1; SMN2MEN1CNR2 | |
| SCHEMBL8046685 | 0.83 | CYP2C19 (0.44) | PPARGPPARAKMT2AALDH1A1TDP1 | |
| SCHEMBL5060638 | 0.81 | KMT2A (0.44) | ATMPPARGPPARAKMT2A | |
| SCHEMBL5058015 | 0.80 | LMNA (0.44) | KMT2AALDH1A1GAASMN1; SMN2MEN1 | |
| SCHEMBL7608262 | 0.79 | GGH (0.50) | LDHATSHR | |
| SCHEMBL7613151 | 0.77 | MMP12 (0.41) | ALDH1A1TDP1KDM4EGAASMN1; SMN2 | |
| SCHEMBL8061556 | 0.77 | ACP3 (0.49) | ACP3PPARGPPARAKMT2AALDH1A1 | |
| SCHEMBL2486055 | 0.77 | ATM (0.64) | ATMLDHACASRKMT2ATDP1 | |
| SCHEMBL5053282 | 0.76 | SMN1; SMN2 (0.41) | ATMKMT2AALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |
| EP-0936914-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0936914-A4 | — | — | 1999-08-25 | — | — | EP | disclosed |
| WO-1997048400-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | disclosed |