Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 5/20 | 0.56 |
| ▸ | BIRC5 | O15392 | 2/20 | 0.56 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | UPP1 | Q16831 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529006 | 0.81 | MDM2 (0.47) | PIM1BIRC5MDM2KDM4EALDH1A1 | |
| SCHEMBL3479396 | 0.81 | KDM4E (0.53) | PIM1MDM2KDM4EALDH1A1GAA | |
| SCHEMBL9754547 | 0.78 | MCL1 (0.55) | PIM1MDM2KDM4EALDH1A1GAA | |
| SCHEMBL7649493 | 0.77 | KDM4E (0.56) | PIM1MDM2KDM4EALDH1A1GAA | |
| SCHEMBL4474609 | 0.76 | MDM2 (0.62) | PIM1BIRC5MDM2KDM4EALDH1A1 | |
| SCHEMBL8962806 | 0.74 | IDO1 (0.56) | PIM1BIRC5BCL2L1KDM4EALDH1A1 | |
| SCHEMBL7319990 | 0.74 | KDM4E (0.67) | PIM1BIRC5KDM4EALDH1A1GAA | |
| SCHEMBL9536884 | 0.74 | KDM4E (0.46) | PIM1MDM2KDM4EALDH1A1GAA | |
| SCHEMBL7646365 | 0.74 | PDE5A (0.50) | MDM2KDM4EALDH1A1GAAGLA | |
| SCHEMBL9701575 | 0.73 | MDM2 (0.59) | PIM1BIRC5MDM2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046216-A | USEFUL TO INHIBIT THE GROWTH OF NEOPLASTIC CELLS. | CELL PATHWAYS, INC. (US) | 2000-04-04 | — | — | US | disclosed |
| EP-0347027-B1 | Phenylpyridone derivatives,processes for their preparation and pharmaceutical compositions containing them. | SMITH KLINE FRENCH LAB (GB) | 1994-08-03 | — | — | EP | disclosed |
| US-5254571-A | Bronchodilators, antiallergens | SMITH KLINE & FRENCH LABORATORIES LTD. (GB) | 1993-10-19 | — | — | US | disclosed |
| EP-0347027-A2 | Phenylpyridone derivatives,processes for their preparation and pharmaceutical compositions containing them. | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-12-20 | — | — | EP | disclosed |