Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | PIM1 | P11309 | 3/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | TYMP | P19971 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | USP8 | P40818 | 1/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536884 | 0.84 | KDM4E (0.46) | MCL1PIM1CA1CA2KDM4E | |
| SCHEMBL9535550 | 0.78 | ALDH1A1 (0.53) | MCL1PIM1CA1CA2KDM4E | |
| SCHEMBL9529006 | 0.78 | MDM2 (0.47) | MCL1PIM1KDM4EGAAALDH1A1 | |
| SCHEMBL8064436 | 0.78 | PIM1 (0.56) | MCL1PIM1KDM4EGAAALDH1A1 | |
| SCHEMBL3479396 | 0.78 | KDM4E (0.53) | MCL1PIM1KDM4EGAAALDH1A1 | |
| SCHEMBL9538291 | 0.77 | ACVR1 (0.43) | KDM4EGAAALDH1A1GLAL3MBTL1 | |
| SCHEMBL9539748 | 0.75 | FASN (0.46) | MCL1PIM1KDM4EGAAALDH1A1 | |
| SCHEMBL9538008 | 0.75 | MDM2 (0.42) | MCL1PIM1CA1CA2KDM4E | |
| SCHEMBL7649493 | 0.75 | KDM4E (0.56) | PIM1KDM4EGAAALDH1A1GLA | |
| SCHEMBL28203557 | 0.75 | CA1 (0.60) | MCL1PIM1CA1CA2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991017987-A1 | PHENOL AND PYRIDINOL DERIVATIVES AS PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-11-28 | — | — | WO | disclosed |