Triforine

Triforine

SCHEMBL8064620

O=CNC(N1CCN(C(NC=O)C(Cl)(Cl)Cl)CC1)C(Cl)(Cl)Cl.O=CNC(N1CCN(C(NC=O)C(Cl)(Cl)Cl)CC1)C(Cl)(Cl)Cl

nearest known ligand 0.34

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.34
HPGD P15428 3/20 0.34
CYP2C19 P33261 2/20 0.34
CYP1A2 P05177 1/20 0.34
MAPT P10636 1/20 0.33
POLB P06746 1/20 0.31
KDM4E B2RXH2 1/20 0.31
GAA P10253 1/20 0.31
CYP2C9 P11712 1/20 0.31
TAAR1 Q96RJ0 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Triforine SCHEMBL23278 1.00 ALDH1A1 (0.34) ALDH1A1HPGDCYP2C19CYP1A2MAPT
Triforine SCHEMBL10335796 0.90 POLB (0.31) ALDH1A1HPGDCYP2C19CYP1A2POLB
Triforine SCHEMBL11829811 0.90 ALDH1A1 (0.39) ALDH1A1HPGDCYP2C19CYP1A2MAPT
SCHEMBL7180786 0.90 ALDH1A1 (0.44) ALDH1A1HPGDCYP2C19CYP1A2MAPT
SCHEMBL3363797 0.86 POLB (0.45) ALDH1A1HPGDCYP2C19CYP1A2MAPT
SCHEMBL9652015 0.86 POLB (0.31) ALDH1A1HPGDCYP2C19CYP1A2POLB
SCHEMBL13406758 0.86 ALDH1A1 (0.31) ALDH1A1MAPT
Hydrochloric Acid SCHEMBL10987504 0.85 POLB (0.30) POLB
Cadaverine Tartrate SCHEMBL11856072 0.75 POLB (0.33) ALDH1A1HPGDCYP2C19CYP1A2POLB
SCHEMBL9274708 0.68

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6136753-A Method for treating fungus in plants WILSON RICHARD (US) 2000-10-24 US disclosed
US-5863909-A CONSISTS OF SORBITAN/FATTY ACID ESTER SURFACTANT AND OTHER SURFACTANT SELECTED FROM RESIN ACID AND ANIONIC OLIGOMER OR POLYMER TYPE QUATERNARY AMMONIUM SALTS KAO CORPORATION (JP) 1999-01-26 US disclosed
US-5458877-A Artificial soil TAKEDA GARDEN PRODUCTS CO., LTD. (JP) 1995-10-17 US disclosed
EP-0409186-B1 Artificial bed soil TAKEDA GARDEN PROD (JP) 1993-12-22 EP disclosed
EP-0409186-A2 Artificial bed soil TAKEDA GARDEN PRODUCTS CO., LTD. (JP) 1991-01-23 EP disclosed