Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HK1 | P19367 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24629878 | 0.69 | AR (0.41) | ARSMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL26581297 | 0.68 | TSHR (0.38) | ARNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL13767120 | 0.66 | KDM4E (0.42) | NPC1LMNAMAPTRAB9AMDM2 | |
| SCHEMBL12320911 | 0.63 | AR (0.36) | ARMEN1KMT2A | |
| SCHEMBL9461239 | 0.63 | PGK1 (0.36) | TSHR | |
| SCHEMBL13735112 | 0.63 | KMT2A (0.42) | ARKDM4EUSP2MEN1KMT2A | |
| SCHEMBL24629973 | 0.62 | MEN1 (0.33) | ARMEN1KMT2A | |
| SCHEMBL24392772 | 0.62 | KDM4E (0.40) | ARLMNAMAPTNPSR1KDM4E | |
| SCHEMBL806475 | 0.62 | RXFP1 (0.49) | ARNPC1LMNAMAPTRAB9A | |
| SCHEMBL29769066 | 0.62 | RXFP1 (0.49) | ARNPC1LMNAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012036253-A1 | HETEROCYCLIC COMPOUNDS FOR TREATING OR PREVENTING DISORDERS CAUSED BY REDUCED NEUROTRANSMISSION OF SEROTONIN, NOREPHNEPHRINE OR DOPAMINE. | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-03-22 | — | — | WO | disclosed |