Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | BRD2 | P25440 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3456302 | 0.83 | AKR1C3 (0.77) | MEN1KMT2AALDH1A1ADRB2TSHR | |
| SCHEMBL23362097 | 0.81 | ALDH1A1 (0.78) | MEN1KMT2AALDH1A1ADRB2TSHR | |
| SCHEMBL4534822 | 0.80 | MEN1 (0.52) | MEN1KMT2AALDH1A1ADRB2TSHR | |
| SCHEMBL31086913 | 0.80 | KMT2A (0.74) | MEN1KMT2AALDH1A1ADRB2TSHR | |
| SCHEMBL28169903 | 0.79 | AKR1C3 (0.68) | MEN1KMT2AALDH1A1ADRB2TSHR | |
| SCHEMBL4534819 | 0.78 | ALDH1A1 (0.54) | MEN1KMT2AALDH1A1ADRB2TSHR | |
| SCHEMBL14893235 | 0.78 | ALDH1A1 (0.57) | MEN1KMT2AALDH1A1AKR1C3MAPT | |
| SCHEMBL31086922 | 0.78 | ALDH1A1 (0.72) | MEN1KMT2AALDH1A1TSHRLMNA | |
| SCHEMBL31086839 | 0.76 | KMT2A (0.69) | MEN1KMT2AALDH1A1TSHRPOLB | |
| SCHEMBL3300404 | 0.75 | ALDH1A1 (0.84) | MEN1KMT2AALDH1A1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |