Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535257 | 0.88 | RAB9A (0.53) | ALDH1A1RAB9APAX8TSHR | |
| SCHEMBL4539052 | 0.86 | ALDH1A1 (0.47) | ALDH1A1RAB9APAX8TSHR | |
| SCHEMBL4536842 | 0.86 | RAB9A (0.50) | ALDH1A1RAB9ATSHRMAPTSMN1; SMN2 | |
| SCHEMBL4535933 | 0.86 | PSEN1 (0.56) | ALDH1A1PAX8TSHRLMNA | |
| SCHEMBL4537565 | 0.86 | RAB9A (0.51) | ALDH1A1RAB9ANPC1 | |
| SCHEMBL4541154 | 0.85 | RAB9A (0.56) | RAB9APAX8 | |
| SCHEMBL8069510 | 0.84 | BRD4 (0.53) | ALDH1A1 | |
| SCHEMBL4538787 | 0.83 | PSEN1 (0.51) | POLBPAX8TSHRLMNA | |
| SCHEMBL4535339 | 0.83 | ATM (0.47) | RAB9APAX8LMNASMN1; SMN2 | |
| SCHEMBL4542333 | 0.83 | PSEN1 (0.51) | POLBPAX8TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |