Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.90 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HMGCR | P04035 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL29802314 | 1.00 | CA4 (0.90) | CA4ALDH1A1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL28068545 | 0.97 | CA4 (0.85) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL28145127 | 0.97 | CA4 (0.85) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL6657504 | 0.97 | CA4 (0.85) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL276987 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL29103874 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL28166887 | 0.95 | CA4 (0.81) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL31415098 | 0.95 | CA4 (0.81) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL852449 | 0.95 | CA4 (0.90) | CA4ALDH1A1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL9405236 | 0.95 | CA4 (0.89) | CA4ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057283-A | REACTING AN EPOXIDIZED FATTY AMIDE WITH ATLEST A CARBOXYALKYL AMINE OR SULFOALKYL AMINE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |
| US-5578561-A | AMORPHOUS ALUMINUM SILICATE | KAO CORPORATION (JP) | 1996-11-26 | — | — | US | disclosed |