Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 6/20 | 0.34 |
| ▸ | KLK5 | Q9Y337 | 5/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.32 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.32 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886373 | 1.00 | NR1H3 (0.37) | NR1H3NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL8886176 | 0.77 | GLA (0.39) | NR1H3NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL5891823 | 0.77 | GLA (0.39) | NR1H3NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL3378115 | 0.71 | CHRM2 (0.40) | NR1H3NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL14141084 | 0.71 | CHRM2 (0.40) | NR1H3NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL8065381 | 0.71 | KLK7 (0.48) | NR1H3NR1H2KLK7KLK5GPR119 | |
| SCHEMBL8886170 | 0.71 | KLK7 (0.48) | NR1H3NR1H2KLK7KLK5GPR119 | |
| SCHEMBL8073190 | 0.70 | NR1H3 (0.36) | NR1H3NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL8886431 | 0.70 | NR1H3 (0.36) | NR1H3NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL8884698 | 0.69 | KLK7 (0.42) | NR1H3NR1H2KLK7KLK5GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666844-B1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1994010138-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | disclosed |