Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.35 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 6/20 | 0.33 |
| ▸ | KLK5 | Q9Y337 | 5/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.30 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.30 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8073190 | 1.00 | NR1H3 (0.36) | NR1H3NR1H2PLA2G10PLA2G5KLK7 | |
| SCHEMBL8078090 | 0.85 | KLK7 (0.39) | NR1H3NR1H2KLK7KLK5GPR119 | |
| SCHEMBL8065148 | 0.84 | NR1H3 (0.36) | NR1H3NR1H2PLA2G10PLA2G5KLK7 | |
| SCHEMBL8885982 | 0.81 | NR1H3 (0.34) | NR1H3NR1H2PLA2G10PLA2G5KLK7 | |
| SCHEMBL8065492 | 0.81 | NR1H3 (0.34) | NR1H3NR1H2PLA2G10PLA2G5KLK7 | |
| SCHEMBL8073393 | 0.81 | NR1H3 (0.34) | NR1H3NR1H2PLA2G10PLA2G5KLK7 | |
| SCHEMBL8886010 | 0.78 | KLK7 (0.48) | NR1H3NR1H2PLA2G10PLA2G5KLK7 | |
| SCHEMBL5891618 | 0.78 | KLK7 (0.48) | NR1H3NR1H2PLA2G10PLA2G5KLK7 | |
| SCHEMBL8884829 | 0.78 | KLK7 (0.48) | NR1H3NR1H2PLA2G10PLA2G5KLK7 | |
| SCHEMBL5891823 | 0.78 | GLA (0.39) | NR1H3NR1H2PLA2G10PLA2G5KLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686472-A | ANTICARCINOGENIC AND -TUMOR AGENTS; SIDE EFFECT REDUCTION; INHIBITION OF FARNESYLATION OF THE RAS PROTEIN | MERCK & CO., INC. (US) | 1997-11-11 | — | — | US | disclosed |