Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.84 |
| ▸ | MAPT | P10636 | 6/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.78 |
| ▸ | RAB9A | P51151 | 1/20 | 0.78 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | MAOB | P27338 | 1/20 | 0.62 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8065947 | 1.00 | MEN1 (0.84) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8063754 | 0.89 | KMT2A (0.77) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8063757 | 0.89 | KMT2A (0.77) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL23547197 | 0.86 | TRPV1 (0.73) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6754378 | 0.86 | TRPV1 (0.73) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6754380 | 0.86 | TRPV1 (0.73) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL15176833 | 0.84 | TRPV1 (1.00) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8049032 | 0.83 | LTB4R (0.84) | MEN1KMT2ASMN1; SMN2MAPTRAB9A | |
| SCHEMBL8049033 | 0.83 | LTB4R (0.84) | MEN1KMT2ASMN1; SMN2MAPTRAB9A | |
| SCHEMBL8061631 | 0.82 | MEN1 (0.71) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127392-A | A MUSCLE RELAXANT FOR TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION; INOTROPIC AGENT | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-10-03 | — | — | US | disclosed |
| US-6046239-A | USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-04-04 | — | — | US | disclosed |