Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | NSD2 | O96028 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | DDX3X | O00571 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8123349 | 0.87 | MEN1 (0.45) | SMN1; SMN2MEN1KMT2AHIF1AALDH1A1 | |
| SCHEMBL8061142 | 0.85 | KDM4E (0.44) | MEN1KMT2AELANEALDH1A1MAPT | |
| SCHEMBL8060295 | 0.85 | RAPGEF3 (0.48) | SMN1; SMN2MEN1KMT2AELANEHIF1A | |
| Water SCHEMBL8066910 | 0.85 | KDM4E (0.49) | ELANEALDH1A1KDM4E | |
| SCHEMBL8060667 | 0.85 | KDM4E (0.49) | ELANEALDH1A1KDM4E | |
| SCHEMBL8064870 | 0.82 | MEN1 (0.54) | SMN1; SMN2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8060382 | 0.80 | KDM4E (0.46) | SMN1; SMN2MEN1KMT2AELANEALDH1A1 | |
| SCHEMBL8049935 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1KMT2AELANEHIF1A | |
| SCHEMBL8066587 | 0.78 | KDM4E (0.46) | SMN1; SMN2MEN1KMT2AELANEHIF1A | |
| SCHEMBL8061148 | 0.77 | SRC (0.43) | SMN1; SMN2ELANEMAPTHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001941-A1 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS KYNURENINE-3-HYDROXYLASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-05-24 | — | — | EP | claimed |
| WO-1999006375-A1 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS KYNURENINE-3-HYDROXYLASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-02-11 | — | — | WO | claimed |
| EP-1001941-A1 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS KYNURENINE-3-HYDROXYLASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999006375-A1 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS KYNURENINE-3-HYDROXYLASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-02-11 | — | — | WO | disclosed |