Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060667 | 0.92 | KDM4E (0.49) | KDM4EELANEALDH1A1CYP3A4TSHR | |
| Water SCHEMBL8066910 | 0.92 | KDM4E (0.49) | KDM4EELANEALDH1A1CYP3A4TSHR | |
| SCHEMBL8066587 | 0.89 | KDM4E (0.46) | KDM4EELANEMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8061148 | 0.87 | SRC (0.43) | KDM4EELANEMAPTSMN1; SMN2S1PR1 | |
| SCHEMBL8151959 | 0.85 | MAPT (0.38) | KDM4EMAPTSMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL8060295 | 0.84 | RAPGEF3 (0.48) | KDM4EELANEMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8061142 | 0.84 | KDM4E (0.44) | KDM4EELANEMAPTALDH1A1TP53 | |
| SCHEMBL8064870 | 0.83 | MEN1 (0.54) | MAPTSMN1; SMN2ALDH1A1TP53POLB | |
| SCHEMBL8060255 | 0.83 | MAPT (0.36) | KDM4EELANEMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8066701 | 0.80 | SMN1; SMN2 (0.49) | KDM4EELANEMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001941-A1 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS KYNURENINE-3-HYDROXYLASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-05-24 | — | — | EP | claimed |
| WO-1999006375-A1 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS KYNURENINE-3-HYDROXYLASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-02-11 | — | — | WO | claimed |
| EP-1001941-A1 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS KYNURENINE-3-HYDROXYLASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999006375-A1 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS KYNURENINE-3-HYDROXYLASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-02-11 | — | — | WO | disclosed |