SCHEMBL8067451

SCHEMBL8067451

C=CC[C@H](C(C)=O)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.46

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.43
LMNA P02545 1/20 0.43
HTT P42858 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
SLC6A3 Q01959 6/20 0.43
SLC6A2 P23975 5/20 0.43
SLC6A4 P31645 5/20 0.43
CYP2C19 P33261 1/20 0.42
AKR1C3 P42330 1/20 0.38
AKR1C2 P52895 1/20 0.38
FFAR2 O15552 1/20 0.37
KCNQ2 O43526 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8067450 1.00 ALDH1A1 (0.43) ALDH1A1LMNAHTTSMN1; SMN2SLC6A3
SCHEMBL5879184 0.86 SLC6A2 (0.44) ALDH1A1LMNAHTTSMN1; SMN2SLC6A3
SCHEMBL5879212 0.86 CYP2C19 (0.60) ALDH1A1LMNAHTTSMN1; SMN2SLC6A3
SCHEMBL5879216 0.86 CYP2C19 (0.60) ALDH1A1LMNAHTTSMN1; SMN2SLC6A3
SCHEMBL624052 0.86 CYP2C19 (0.60) ALDH1A1LMNAHTTSMN1; SMN2SLC6A3
SCHEMBL5879182 0.86 SLC6A2 (0.44) ALDH1A1LMNAHTTSMN1; SMN2SLC6A3
SCHEMBL623726 0.86 SLC6A2 (0.44) ALDH1A1LMNAHTTSMN1; SMN2SLC6A3
SCHEMBL8329882 0.84 SLC6A2 (0.43) ALDH1A1LMNAHTTSMN1; SMN2SLC6A3
SCHEMBL8329884 0.84 SLC6A2 (0.43) ALDH1A1LMNAHTTSMN1; SMN2SLC6A3
SCHEMBL5879125 0.84 SLC6A3 (0.49) ALDH1A1LMNAHTTSMN1; SMN2SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6013652-A ANTIINFLAMMATORY AGENTS; ANALGESICS; ANTIHISTAMINES MERCK & CO., INC. (US) 2000-01-11 US disclosed
US-6013644-A AIDS THERAPY MERCK & CO., INC. (US) 2000-01-11 US disclosed
US-5962462-A COMPOUNDS WHICH INHIBIT THE ENTRY OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INTO TARGET CELLS; DELAYING THE ONSET OF ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS). MERCK & CO., INC. (US) 1999-10-05 US disclosed
US-5869496-A TREATING ASTHMA, EMESIS MERCK & CO., INC. (US) 1999-02-09 US disclosed
EP-0681571-B1 SPIRO-SUBSTITUTED AZACYCLES AS TACHYKININ RECEPTOR ANTAGONISTS MERCK & CO INC (US) 1998-07-29 EP disclosed
WO-1998025604-A1 SPIRO-SUBSTITUTED AZACYCLES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 1998-06-18 WO disclosed
WO-1998025605-A1 SPIRO-SUBSTITUTED AZACYCLES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 1998-06-18 WO disclosed
EP-0702681-A1 SPIRO-SUBSTITUTED AZACYCLES AS NEUROKININ ANTAGONISTS MERCK & CO. INC. (US) 1996-03-27 EP disclosed
EP-0681571-A1 SPIRO-SUBSTITUTED AZACYCLES AS TACHYKININ RECEPTOR ANTAGONISTS MERCK & CO. INC. (US) 1995-11-15 EP disclosed
WO-1994029309-A1 SPIRO-SUBSTITUTED AZACYCLES AS NEUROKININ ANTAGONISTS MERCK & CO., INC. (US) 1994-12-22 WO disclosed
WO-1994017045-A1 SPIRO-SUBSTITUTED AZACYCLES AS TACHYKININ RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1994-08-04 WO disclosed