Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 13/20 | 1.00 |
| ▸ | CYP17A1 | P05093 | 12/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8067904 | 0.84 | CYP17A1 (1.00) | CYP19A1CYP17A1MEN1KMT2AALDH1A1 | |
| SCHEMBL9334979 | 0.74 | CYP19A1 (1.00) | CYP19A1CYP17A1HSD11B1 | |
| SCHEMBL31239310 | 0.72 | CYP19A1 (0.56) | CYP19A1CYP17A1MEN1KMT2AALDH1A1 | |
| SCHEMBL8899923 | 0.72 | CYP17A1 (1.00) | CYP19A1CYP17A1MEN1KMT2AHSD11B1 | |
| SCHEMBL8897307 | 0.72 | CYP17A1 (1.00) | CYP19A1CYP17A1MEN1KMT2AHSD11B1 | |
| SCHEMBL8897312 | 0.72 | CYP17A1 (1.00) | CYP19A1CYP17A1MEN1KMT2AHSD11B1 | |
| SCHEMBL8077869 | 0.71 | CYP17A1 (1.00) | CYP19A1CYP17A1MEN1KMT2AHSD11B1 | |
| SCHEMBL23746946 | 0.70 | CYP19A1 (0.53) | CYP19A1CYP17A1KMT2AALDH1A1 | |
| SCHEMBL25899389 | 0.69 | CYP19A1 (0.52) | CYP19A1CYP17A1ALDH1A1 | |
| SCHEMBL131064 | 0.69 | CYP17A1 (0.55) | CYP19A1CYP17A1MEN1KMT2AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640072-B1 | Derivatives of pyridine as hydroxylase and lyase inhibitors | BTG INT LTD (GB) | 2000-08-23 | — | — | EP | disclosed |
| US-5595995-A | ANTICARCINOGENIC AGENTS | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1997-01-21 | — | — | US | disclosed |
| EP-0640072-A1 | SUBSTITUTED PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL USE | BTG INTERNATIONAL LIMITED (GB) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993023375-A1 | SUBSTITUTED PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL USE | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1993-11-25 | — | — | WO | disclosed |