Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 9/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | RPA1 | P27694 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CYTH3 | O43739 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | EPN1 | Q9Y6I3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1827221 | 0.87 | MAPK1 (0.47) | ALPLMAPK1HCAR2DAOHCAR3 | |
| SCHEMBL70577 | 0.85 | HCAR2 (0.59) | ALPLTP53CA12MAPK1HCAR2 | |
| SCHEMBL5599765 | 0.83 | HCAR2 (0.53) | MAPK1HCAR2DAOHCAR3CYTH3 | |
| SCHEMBL12943881 | 0.83 | TP53 (0.47) | ALPLTP53CA12MAPK1HCAR2 | |
| SCHEMBL19987833 | 0.83 | HCAR2 (0.57) | ALPLTP53CA12MAPK1HCAR2 | |
| Hydrochloric Acid SCHEMBL11595364 | 0.83 | HCAR2 (0.57) | ALPLTP53CA12MAPK1HCAR2 | |
| Hydrochloric Acid SCHEMBL7723258 | 0.83 | HCAR2 (0.57) | ALPLTP53CA12MAPK1HCAR2 | |
| Water SCHEMBL1267709 | 0.83 | HCAR2 (0.57) | ALPLTP53CA12MAPK1HCAR2 | |
| SCHEMBL28638090 | 0.83 | HCAR2 (0.57) | ALPLTP53CA12MAPK1HCAR2 | |
| SCHEMBL13279353 | 0.82 | MAPK1 (0.47) | MAPK1HCAR2DAOHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110582485-B | Pyrazole derivatives as bromodomain inhibitors | 葛兰素史克知识产权第二有限公司 | 2023-10-13 | — | — | CN | disclosed |
| EP-0565351-B1 | Process for preparing 7-substituted-amino-3-hydroxy-3-cephem-4-protected carboxy-sulfoxide esters | LILLY CO ELI (US) | 2000-08-23 | — | — | EP | disclosed |
| US-5512454-A | Enzymatic acylation of 3-hydroxymethyl cephalosporins | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-04-30 | — | — | US | disclosed |
| US-5350845-A | Process for preparing 7-substituted-amino-3-hydroxy-3-cephem-4-protected carboxy-sulfoxide esters | ELI LILLY AND COMPANY (US) | 1994-09-27 | — | — | US | disclosed |
| EP-0611770-A2 | A process for preparing acid halides | ELI LILLY AND COMPANY (US) | 1994-08-24 | — | — | EP | disclosed |
| EP-0565351-A2 | Process for preparing 7-substituted-amino-3-hydroxy-3-cephem-4-protected carboxy-sulfoxide esters | ELI LILLY AND COMPANY (US) | 1993-10-13 | — | — | EP | disclosed |
| US-5221739-A | Acetylation of 3-hydroxymethyl cephalosporins | ELI LILLY AND COMPANY (US) | 1993-06-22 | — | — | US | disclosed |
| EP-0232623-B1 | 1-CARBACEPHALOSPORIN ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1993-03-17 | — | — | EP | disclosed |
| EP-0511002-A2 | C-3 phosphine oxide substituted carbacephalosporins | ELI LILLY AND COMPANY (US) | 1992-10-28 | — | — | EP | disclosed |
| EP-0494733-A1 | Trifluoromethyl 1-carba(1-dethia)cephems | ELI LILLY AND COMPANY (US) | 1992-07-15 | — | — | EP | disclosed |
| EP-0494118-A1 | Process for 3-exomethylenecepham sulfoxide esters | ELI LILLY AND COMPANY (US) | 1992-07-08 | — | — | EP | disclosed |
| US-5099015-A | Antibiotics formed by bromination of trifluoromethanesulfonyl containing cephalosporins | ELI LILLY AND COMPANY (US) | 1992-03-24 | — | — | US | disclosed |
| US-5084568-A | Process for preparing acid halides | ELI LILLY AND COMPANY (US) | 1992-01-28 | — | — | US | disclosed |
| US-5084447-A | Antibiotics as bactericides | ELI LILLY AND COMPANY (US) | 1992-01-28 | — | — | US | disclosed |
| US-5013854-A | Process for preparing acid halides | ELI LILLY AND COMPANY (US) | 1991-05-07 | — | — | US | disclosed |
| US-4892942-A | 1-CARBA (DETHIA)CEPHALOSPORINS | ELI LILLY AND COMPANY (US) | 1990-01-09 | — | — | US | disclosed |
| US-4885291-A | 1-carba(dethia)-3-cephem derivatives | ELI LILLY AND COMPANY (US) | 1989-12-05 | — | — | US | disclosed |
| US-4791106-A | 1-Carbacephalosporin antibiotics | ELI LILLY AND COMPANY (US) | 1988-12-13 | — | — | US | disclosed |
| EP-0232623-A1 | 1-Carbacephalosporin antibiotics | ELI LILLY AND COMPANY (US) | 1987-08-19 | — | — | EP | disclosed |