Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 9/20 | 0.69 |
| ▸ | TRPC6 | Q9Y210 | 9/20 | 0.69 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.62 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.62 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.62 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.62 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.62 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | TPH1 | P17752 | 5/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LHCGR | P22888 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807015 | 0.82 | TRPC3 (1.00) | TRPC3TRPC6TRPV1TRPA1CACNA1C | |
| SCHEMBL30186173 | 0.77 | TRPC3 (1.00) | TRPC3TRPC6TRPV1TRPA1CACNA1C | |
| SCHEMBL798463 | 0.77 | TRPC3 (1.00) | TRPC3TRPC6TRPV1TRPA1CACNA1C | |
| SCHEMBL26459111 | 0.77 | TRPC3 (1.00) | TRPC3TRPC6TRPV1TRPA1CACNA1C | |
| SCHEMBL790044 | 0.77 | TRPC3 (0.71) | TRPC3TRPC6TRPV1TRPA1CACNA1C | |
| SCHEMBL26459144 | 0.74 | TRPC3 (0.72) | TRPC3TRPC6TRPV1TRPA1CACNA1C | |
| SCHEMBL790188 | 0.74 | TRPC3 (0.72) | TRPC3TRPC6TRPV1TRPA1CACNA1C | |
| SCHEMBL788893 | 0.72 | TRPC3 (0.61) | TRPC3TRPC6TRPV1TRPA1CACNA1C | |
| SCHEMBL26458205 | 0.68 | TRPC3 (0.83) | TRPC3TRPC6TRPV1TRPA1CACNA1C | |
| SCHEMBL26458213 | 0.68 | TRPC3 (0.83) | TRPC3TRPC6TRPV1TRPA1CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037349-A2 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |