Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8072552 | 0.99 | SIRT2 (0.42) | SIRT2OPRK1CTSLSIRT5MMP2 | |
| Hydrochloric Acid SCHEMBL8069339 | 0.86 | HTT (0.50) | SIRT2CTSLMMP2MMP9KEAP1 | |
| SCHEMBL7600261 | 0.85 | SIRT2 (0.44) | SIRT2CTSLSIRT5MMP2MMP9 | |
| Hydrochloric Acid SCHEMBL7595781 | 0.84 | SIRT2 (0.43) | SIRT2CTSLSIRT5MMP2MMP9 | |
| SCHEMBL7318212 | 0.80 | FOLH1 (0.58) | SIRT2MMP2MMP9KEAP1NFE2L2 | |
| SCHEMBL7311020 | 0.80 | FOLH1 (0.58) | SIRT2MMP2MMP9KEAP1NFE2L2 | |
| SCHEMBL19013589 | 0.80 | FOLH1 (0.55) | SIRT2CTSLSIRT5MMP2MMP9 | |
| SCHEMBL21623619 | 0.80 | FOLH1 (0.55) | SIRT2CTSLSIRT5MMP2MMP9 | |
| SCHEMBL16869920 | 0.80 | FOLH1 (0.55) | SIRT2CTSLSIRT5MMP2MMP9 | |
| SCHEMBL8063017 | 0.79 | NPY1R (0.37) | CTSLFOLH1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017672-A1 | NEW NPY ANTAGONISTS | AstraZeneca AB (SE) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015498-A1 | NEW NPY ANTAGONISTS | ASTRAZENECA AB (SE) | 1999-04-01 | — | — | WO | disclosed |