Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 11/20 | 0.62 |
| ▸ | CYP19A1 | P11511 | 9/20 | 0.62 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.53 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8067920 | 1.00 | CYP17A1 (0.62) | CYP17A1CYP19A1HSD11B1P2RX7USP2 | |
| SCHEMBL8067921 | 1.00 | CYP17A1 (0.62) | CYP17A1CYP19A1HSD11B1P2RX7USP2 | |
| SCHEMBL8068078 | 0.84 | CYP17A1 (0.59) | CYP17A1CYP19A1HSD11B1P2RX7MEN1 | |
| SCHEMBL8068085 | 0.84 | CYP17A1 (0.59) | CYP17A1CYP19A1HSD11B1P2RX7MEN1 | |
| SCHEMBL8080716 | 0.84 | CYP17A1 (0.59) | CYP17A1CYP19A1HSD11B1P2RX7MEN1 | |
| SCHEMBL8897307 | 0.77 | CYP17A1 (1.00) | CYP17A1CYP19A1HSD11B1P2RX7USP2 | |
| SCHEMBL3324030 | 0.77 | CYP17A1 (0.72) | CYP17A1CYP19A1HSD11B1P2RX7USP2 | |
| SCHEMBL8899923 | 0.77 | CYP17A1 (1.00) | CYP17A1CYP19A1HSD11B1P2RX7USP2 | |
| SCHEMBL8897312 | 0.77 | CYP17A1 (1.00) | CYP17A1CYP19A1HSD11B1P2RX7USP2 | |
| SCHEMBL9467735 | 0.76 | L3MBTL1 (0.51) | CYP17A1CYP19A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640072-B1 | Derivatives of pyridine as hydroxylase and lyase inhibitors | BTG INT LTD (GB) | 2000-08-23 | — | — | EP | disclosed |
| US-5595995-A | ANTICARCINOGENIC AGENTS | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1997-01-21 | — | — | US | disclosed |
| EP-0640072-A1 | SUBSTITUTED PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL USE | BTG INTERNATIONAL LIMITED (GB) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993023375-A1 | SUBSTITUTED PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL USE | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1993-11-25 | — | — | WO | disclosed |