Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8059748 | 0.81 | HSD17B10 (0.66) | HSD17B10MAPK1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8068689 | 0.81 | HSD17B10 (1.00) | HSD17B10MAPK1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL17554026 | 0.77 | ALDH1A1 (0.55) | MAPK1ALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL17554069 | 0.76 | C1R (0.52) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL17554078 | 0.75 | MAPK1 (0.56) | HSD17B10MAPK1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL914362 | 0.75 | ALDH1A1 (0.67) | HSD17B10MAPK1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8070457 | 0.74 | ALDH1A1 (0.48) | HSD17B10MAPK1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8070379 | 0.73 | KDM4E (0.75) | HSD17B10MAPK1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL29307853 | 0.73 | HSD17B10 (0.58) | HSD17B10MAPK1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8059761 | 0.73 | MAPK1 (0.72) | HSD17B10MAPK1ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150372-A | IMMUNOINFLAMMATORY AND AUTOIMMUNE DISEASES; BLOCKING INTRACELLULAR SIGNAL TRANSDUCTION AND ACTIVATION OF TRANSCRIPTION FACTORS; KINASE INHIBITORS; ANTIARTHRITIC, ISCHEMIC AGENTS, MULTIPLE SCLEROSIS, TRANSPLANT REJECTION | SIGNAL PHARMACEUTICALS, INC. (US) | 2000-11-21 | — | — | US | disclosed |
| US-5939421-A | TREATMENT OF IMMUNOINFLAMMATORY AND AUTOIMMUNE DISEASES SUCH AS RHEUMATOID ARTHRITIS, TRANSPLANT REJECTION; INHIBIT KINASE(S) THAT REGULATE ACTIVATION OF TRANSCRIPTION FACTORS TO PREVENT PRODUCTION OF INFLAMMATORY PROTEINS | SIGNAL PHARMACEUTICALS, INC. (US) | 1999-08-17 | — | — | US | disclosed |
| WO-1999001441-A1 | QUINAZOLINE ANALOGS AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1999-01-14 | — | — | WO | disclosed |