Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 11/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17571412 | 0.83 | TSHR (0.46) | OPRD1NPC1RAB9ATSHRGAA | |
| SCHEMBL19435319 | 0.83 | TSHR (0.46) | OPRD1NPC1RAB9ATSHRGAA | |
| SCHEMBL18085367 | 0.78 | OPRD1 (0.49) | OPRD1OPRK1TSHRKMT2ABCHE | |
| SCHEMBL3300446 | 0.76 | TSHR (0.49) | OPRK1NPC1RAB9ATSHRGAA | |
| SCHEMBL3300438 | 0.76 | TSHR (0.49) | OPRK1NPC1RAB9ATSHRGAA | |
| SCHEMBL12126189 | 0.76 | TSHR (0.48) | OPRD1OPRK1NPC1RAB9ATSHR | |
| SCHEMBL1236268 | 0.75 | TSHR (0.55) | OPRK1NPC1RAB9ATSHRGAA | |
| SCHEMBL9816880 | 0.75 | BCHE (0.51) | OPRD1OPRK1NPC1RAB9ATSHR | |
| SCHEMBL9816883 | 0.75 | BCHE (0.51) | OPRD1OPRK1NPC1RAB9ATSHR | |
| SCHEMBL1198741 | 0.74 | S1PR2 (0.43) | OPRD1NPC1RAB9AKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |