Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | XBP1 | P17861 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.57 |
| ▸ | FBP1 | P09467 | 1/20 | 0.56 |
| ▸ | MYC | P01106 | 1/20 | 0.55 |
| ▸ | WDR5 | P61964 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6285194 | 0.92 | KDM4E (0.61) | MAPTKDM4EMAPK1SMN1; SMN2NPSR1 | |
| Bromide SCHEMBL5698583 | 0.90 | KDM4E (0.59) | MAPTKDM4EMAPK1SMN1; SMN2NPSR1 | |
| SCHEMBL20703532 | 0.87 | MAPT (0.58) | MAPTKDM4EMAPK1SMN1; SMN2NPSR1 | |
| SCHEMBL1304933 | 0.85 | MAPT (0.78) | MAPTKDM4EMAPK1SMN1; SMN2NPSR1 | |
| SCHEMBL5205345 | 0.83 | TGFBR1 (0.53) | MAPTKDM4EMAPK1SMN1; SMN2NPSR1 | |
| SCHEMBL22048445 | 0.83 | SMN1; SMN2 (0.52) | MAPTKDM4EMAPK1SMN1; SMN2NPSR1 | |
| SCHEMBL29272745 | 0.82 | MYC (0.57) | MAPTKDM4EMAPK1SMN1; SMN2NPSR1 | |
| SCHEMBL18041639 | 0.82 | TGFBR1 (0.65) | MAPTKDM4EMAPK1SMN1; SMN2NPSR1 | |
| Propane SCHEMBL6449399 | 0.82 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL25352230 | 0.81 | MAPT (1.00) | MAPTKDM4EMAPK1SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0592664-B1 | DERIVATIVES OF DIPHENYLTHIAZOLE WITH ANTIINFLAMMATORY ACTIVITY | HISAMITSU PHARMACEUTICAL CO (JP) | 2000-07-05 | — | — | EP | disclosed |
| US-5449783-A | Antiinflammatory, analgesic, antiallergic, diuretic agents, anticoagulants | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 1995-09-12 | — | — | US | disclosed |
| EP-0592664-A1 | NOVEL DIPHENYLTHYAZOLE DERIVATIVE | Hisamitsu Pharmaceutical Co., Inc. (JP) | 1994-04-20 | — | — | EP | disclosed |