⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27858299 | 0.97 | ADH1B (0.43) | — | |
| SCHEMBL5237219 | 0.86 | — | — | |
| SCHEMBL8068066 | 0.77 | ADH1B (0.46) | — | |
| SCHEMBL269618 | 0.75 | — | — | |
| SCHEMBL11423071 | 0.73 | ADH1B (0.42) | — | |
| SCHEMBL13074302 | 0.73 | — | — | |
| SCHEMBL25180 | 0.73 | — | — | |
| SCHEMBL14399676 | 0.73 | ADH1B (0.54) | — | |
| SCHEMBL21336465 | 0.72 | — | — | |
| SCHEMBL7753100 | 0.71 | ADH1B (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106083714-B | N- (4- { [bis- (methyl oxygroup) quinolyl-4s of 6,7-] oxygroup } phenyl)-N '-(4- fluorophenyl) cyclopropane -1,1- diformamide malate and its crystal type | 埃克塞里艾克西斯公司 | 2019-11-26 | — | — | CN | claimed |
| CN-105153028-B | Compound as c-Met kinase inhibitor | 南京爱德程医药科技有限公司 | 2019-03-26 | — | — | CN | claimed |
| CN-103748074-B | Aryloxy group quinoline derivatives and therapeutical uses thereof | TIANJIN LONGBOGEN PHARMACEUTICAL Co.,Ltd. (CN) | 2016-05-18 | — | — | CN | claimed |
| CN-110511158-A | The method for preparing quinoline | EXELIXIS INC | 2019-11-29 | — | — | CN | disclosed |
| CN-106083714-B | N- (4- { [bis- (methyl oxygroup) quinolyl-4s of 6,7-] oxygroup } phenyl)-N '-(4- fluorophenyl) cyclopropane -1,1- diformamide malate and its crystal type | 埃克塞里艾克西斯公司 | 2019-11-26 | — | — | CN | disclosed |
| CN-110352057-A | Combination of cabozantinib and astuzumab for treatment of cancer | 埃克塞里艾克西斯公司 | 2019-10-18 | — | — | CN | disclosed |
| CN-104370811-B | A kind of novel crystal forms of quinoline compound and preparation method thereof | 广东东阳光药业有限公司 | 2019-02-12 | — | — | CN | disclosed |
| CN-109069499-A | Use N- (4- (6,7- dimethoxy-quinoline -4- base oxygroup) phenyl)-N '-(4- fluorophenyl) cyclopropane -1,1- diformamide, the method for (2S)-hydroxysuccinic acid salts for treating clear-cell carcinoma | 埃克塞里艾克西斯公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-108929324-A | The preparation and application of novel 1,1- cyclopropyl diamide derivatives | 南开大学 | 2018-12-04 | — | — | CN | disclosed |
| CN-108530464-A | A kind of multiple target point kinase inhibitor | 深圳海王医药科技研究院有限公司 | 2018-09-14 | — | — | CN | disclosed |
| CN-108472242-A | Pharmaceutical composition for treating cancer | 埃克塞里艾克西斯公司 | 2018-08-31 | — | — | CN | disclosed |
| CN-101932586-A | Inhibition of protein tyrosine kinase activity | METHYLGENE INC | 2010-12-29 | — | — | CN | disclosed |
| CN-101796055-A | Inhibitors of VEGF receptor and HGF receptor signaling | METHYLGENE INC | 2010-08-04 | — | — | CN | disclosed |
| EP-1018536-A1 | LUMINESCENT PLASTIC MATERIAL AND PROCESS FOR PRODUCING THE SAME | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 2000-07-12 | — | — | EP | disclosed |
| EP-0927745-A1 | OPTICAL PLASTIC MATERIAL AND PROCESS FOR THE PRODUCTION THEREOF | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1999-07-07 | — | — | EP | disclosed |
| EP-0036129-B1 | PROCESS FOR THE PREPARATION OF IMIDAZOLES | BASF Aktiengesellschaft (DE) | 1984-06-13 | — | — | EP | disclosed |
| EP-0025191-B1 | PROCESS FOR THE PREPARATION OF IMIDAZOLES | BASF Aktiengesellschaft (DE) | 1983-05-25 | — | — | EP | disclosed |
| US-4340744-A | METAL OXIDES AS CATALYSTS | BASF AKTIENGESELLSCHAFT (DE) | 1982-07-20 | — | — | US | disclosed |
| EP-0036129-A1 | Process for the preparation of imidazoles | BASF Aktiengesellschaft (DE) | 1981-09-23 | — | — | EP | disclosed |
| EP-0025191-A1 | Process for the preparation of imidazoles | BASF Aktiengesellschaft (DE) | 1981-03-18 | — | — | EP | disclosed |