Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.32 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.32 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558278 | 0.98 | ALDH1A1 (0.57) | ALDH1A1MAPK1SMN1; SMN2PIK3CDPIK3CA | |
| Bromide SCHEMBL7480303 | 0.77 | ALDH1A1 (0.56) | ALDH1A1MAPK1SMN1; SMN2PIK3CDPIK3CA | |
| Bromide SCHEMBL3450128 | 0.74 | ALDH1A1 (0.96) | ALDH1A1MAPK1SMN1; SMN2PIK3CDPIK3CA | |
| SCHEMBL170013 | 0.72 | ALDH1A1 (1.00) | ALDH1A1MAPK1SMN1; SMN2PIK3CDPIK3CA | |
| SCHEMBL8073165 | 0.71 | KDM4E (0.33) | ALDH1A1POLBRAB9A | |
| Hydrochloric Acid SCHEMBL30189955 | 0.70 | ALDH1A1 (0.96) | ALDH1A1MAPK1SMN1; SMN2PIK3CDPIK3CA | |
| SCHEMBL2429975 | 0.70 | ALDH1A1 (0.46) | ALDH1A1MAPK1SMN1; SMN2PIK3CDPIK3CA | |
| SCHEMBL6862670 | 0.70 | ALDH1A1 (0.63) | ALDH1A1MAPK1SMN1; SMN2PIK3CDPIK3CA | |
| SCHEMBL167247 | 0.68 | ALDH1A1 (0.61) | ALDH1A1MAPK1SMN1; SMN2PIK3CDPIK3CA | |
| SCHEMBL2035154 | 0.68 | ALDH1A1 (0.61) | ALDH1A1MAPK1SMN1; SMN2PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043373-A | ANTIULCER AGENT | YUNGJIN PHARMACEUTICAL CO., LTD. (KR) | 2000-03-28 | — | — | US | disclosed |