Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 8/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.46 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.46 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8073502 | 0.87 | TTR (0.51) | SRD5A2POLBTTRALDH1A1 | |
| SCHEMBL7995261 | 0.83 | TTR (0.61) | SRD5A2POLBTTRTDP1ALDH1A1 | |
| SCHEMBL8059681 | 0.82 | TTR (0.45) | POLBTTR | |
| SCHEMBL8059364 | 0.82 | PKM (0.55) | POLBTTRTDP1ALDH1A1 | |
| SCHEMBL8070954 | 0.82 | PKM (0.50) | KDM4ETTRALDH1A1 | |
| SCHEMBL28738308 | 0.80 | TBXA2R (0.62) | MEN1KMT2AKDM4ETBXA2R | |
| SCHEMBL17185272 | 0.79 | SRD5A2 (0.61) | SRD5A2MEN1KMT2AKDM4ETTR | |
| SCHEMBL8068490 | 0.79 | TTR (0.44) | KMT2APOLBTTRALDH1A1 | |
| SCHEMBL8375480 | 0.78 | HPGD (0.45) | KDM4EPOLBTTRALDH1A1 | |
| SCHEMBL8375481 | 0.78 | HPGD (0.45) | KDM4EPOLBTTRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057322-A | USEFUL IN TREATMENT OF CARDIOVASCULAR DISEASES | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |
| EP-0723956-B1 | Basically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics as well as medicaments containing them | HOECHST AG (DE) | 1999-10-13 | — | — | EP | disclosed |
| EP-0723956-A1 | Basically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics as well as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-31 | — | — | EP | disclosed |