Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ABL2 | P42684 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8375481 | 1.00 | HPGD (0.45) | HPGDHTTTTRPKMABL1 | |
| SCHEMBL8379051 | 0.88 | VCAM1 (0.43) | HPGDHTTEGFRALDH1A1NPSR1 | |
| SCHEMBL8379048 | 0.88 | VCAM1 (0.43) | HPGDHTTEGFRALDH1A1NPSR1 | |
| SCHEMBL8073502 | 0.87 | TTR (0.51) | TTRPKMALDH1A1NPSR1POLB | |
| SCHEMBL7995261 | 0.83 | TTR (0.61) | TTRPKMALDH1A1NPSR1POLB | |
| SCHEMBL8070954 | 0.82 | PKM (0.50) | TTRPKMALDH1A1TSHRNPSR1 | |
| SCHEMBL8059364 | 0.80 | PKM (0.55) | HTTTTRPKMALDH1A1POLB | |
| SCHEMBL8059681 | 0.80 | TTR (0.45) | TTRPKMNPSR1POLBAPEX1 | |
| SCHEMBL8068490 | 0.79 | TTR (0.44) | TTRPKMALDH1A1NPSR1POLB | |
| SCHEMBL8070909 | 0.78 | SRD5A2 (0.56) | TTRALDH1A1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5880156-A | ANTIARRHYTHMIA AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |