Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.36 |
| ▸ | DRD5 | P21918 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL345477 | 1.00 | KMT2A (0.41) | KMT2ALMNAMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL5889366 | 1.00 | KMT2A (0.41) | KMT2ALMNAMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL10439319 | 0.90 | KDM4E (0.45) | KMT2AKDM4EALDH1A1MTNR1AMTNR1B | |
| SCHEMBL5889377 | 0.87 | CYP1A2 (0.49) | KMT2ALMNAMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL5889344 | 0.87 | CYP1A2 (0.49) | KMT2ALMNAMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL346280 | 0.87 | CYP1A2 (0.49) | KMT2ALMNAMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL5889376 | 0.87 | CYP1A2 (0.49) | KMT2ALMNAMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL346652 | 0.84 | DRD2 (0.39) | KMT2AKDM4EALDH1A1MTNR1AMTNR1B | |
| SCHEMBL7457086 | 0.80 | PDE4B (0.51) | — | |
| SCHEMBL19669833 | 0.78 | ALDH1A1 (0.54) | KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017667-A1 | 2-Amino-6-methyl-7-acetyl-tetraline and pharmaceutical compositions for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015494-A1 | 2-AMINOTETRALINES, A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS, FOR THE PREVENTION AND THERAPEUTIC TREATMENT OF INFLAMMATORY AND/OR AUTOIMMUNE PATHOLOGIES | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1999-04-01 | — | — | WO | disclosed |