Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 13/20 | 0.47 |
| ▸ | CNR2 | P34972 | 13/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TLR3 | O15455 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582825 | 0.81 | CNR1 (0.45) | CNR1CNR2HTR2AAKR1B1 | |
| SCHEMBL617187 | 0.78 | TRPM8 (0.36) | CNR1CNR2HTR2AAKR1B1 | |
| SCHEMBL11480145 | 0.77 | TRPM8 (0.35) | CNR1CNR2HTR2AAKR1B1 | |
| SCHEMBL23422963 | 0.74 | KMT2A (0.36) | CNR1CNR2HTR2AKCNH2AKR1B1 | |
| SCHEMBL8071498 | 0.71 | KCNE1 (0.35) | HTR2AAKR1B1USP2MAPT | |
| SCHEMBL8071499 | 0.71 | KCNE1 (0.35) | HTR2AAKR1B1USP2MAPT | |
| SCHEMBL8071501 | 0.71 | KCNE1 (0.35) | HTR2AAKR1B1USP2MAPT | |
| SCHEMBL11255709 | 0.69 | SLC6A2 (0.40) | CNR1CNR2HTR2A | |
| SCHEMBL8069942 | 0.69 | TLR3 (0.41) | CNR1CNR2AKR1B1TLR3 | |
| SCHEMBL11476102 | 0.68 | CNR1 (0.35) | CNR1CNR2HTR2AAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071953-A | Sulfonamide-substituted chromans, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-06-06 | — | — | US | disclosed |
| EP-0860440-A1 | Sulfonamido substituted chromane derivatives with potassium channel blocking activity | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-08-26 | — | — | EP | disclosed |