SCHEMBL807159

SCHEMBL807159

FC(F)(F)Oc1ccc2c(c1)CNCCO2

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 1/20 0.38
CES1 P23141 1/20 0.36
HTR6 P50406 3/20 0.36
S1PR1 P21453 2/20 0.36
S1PR3 Q99500 2/20 0.36
ACHE P22303 1/20 0.35
CHRM5 P08912 1/20 0.35
GPR3 P46089 1/20 0.35
SCN4A P35499 2/20 0.34
SCN9A Q15858 2/20 0.34
HTR2C P28335 1/20 0.34
KIF11 P52732 1/20 0.34
NISCH Q9Y2I1 1/20 0.33
PTGS1 P23219 1/20 0.33
PTGS2 P35354 1/20 0.33
SCN1A P35498 1/20 0.33
KCNH2 Q12809 1/20 0.33
SCN5A Q14524 1/20 0.33
SCN2A Q99250 1/20 0.33
SCN3A Q9NY46 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14480723 0.89 CA12 (0.42) ABL1S1PR1S1PR3SCN4ASCN9A
SCHEMBL4789785 0.80 KCNH2 (0.51) S1PR1S1PR3HTR2CNISCHKCNH2
SCHEMBL31020322 0.80 KCNH2 (0.51) S1PR1S1PR3HTR2CNISCHKCNH2
SCHEMBL30616492 0.77 CTNNB1 (0.41) CES1CHRM5GPR3PTGS1PTGS2
SCHEMBL18254949 0.77 ASIC3 (0.41) S1PR1S1PR3ACHEHTR2C
SCHEMBL17384160 0.77 CTNNB1 (0.41) CES1CHRM5GPR3PTGS1PTGS2
SCHEMBL7979150 0.75 ASIC3 (0.50) HTR2C
SCHEMBL6979583 0.75 PNMT (0.50)
SCHEMBL17927769 0.74 FABP6 (0.49) S1PR1S1PR3ACHEHTR2C
SCHEMBL3878859 0.74 CES1 (0.44) ABL1CES1GPR3SCN4ASCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012037105-A1 METHODS OF TREATING, AMELIORATING OR PREVENTING STRESS-INDUCED NEURONAL DISORDERS AND DISEASES THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-03-22 WO disclosed
WO-2012019076-A1 COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING CARDIAC ISCHEMIA/REPERFUSION INJURY THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-02-09 WO disclosed
WO-2012019071-A1 METHODS OF PREVENTING AND TREATING SARCOPENIA THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-02-09 WO disclosed
WO-2008144483-A2 AGENTS FOR TREATING DISORDERS INVOLVING MODULATION OF RYANODINE RECEPTORS ARMGO PHARMA, INC. (US) 2008-11-27 WO disclosed
WO-2008144483-A2 AGENTS FOR TREATING DISORDERS INVOLVING MODULATION OF RYANODINE RECEPTORS ARMGO PHARMA, INC. (US) 2008-11-27 WO disclosed