SCHEMBL8072218

SCHEMBL8072218

CC/C=C\CCCCCCCS(=O)(=O)O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 2/20 0.60
ALDH1A1 P00352 5/20 0.47
PPARA Q07869 4/20 0.47
F7 P08709 3/20 0.47
F3 P13726 3/20 0.47
CYP19A1 P11511 3/20 0.47
MAPT P10636 2/20 0.47
CYP3A4 P08684 2/20 0.47
ALOX15 P16050 2/20 0.47
HSD17B10 Q99714 2/20 0.47
TDP1 Q9NUW8 2/20 0.47
OXER1 Q8TDS5 2/20 0.47
PTGS1 P23219 2/20 0.47
PPARG P37231 2/20 0.47
KMT2A Q03164 2/20 0.47
PPARD Q03181 2/20 0.47
KDM4E B2RXH2 1/20 0.47
MEN1 O00255 1/20 0.47
FFAR1 O14842 1/20 0.47
NR1I2 O75469 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8072057 1.00 EPHX2 (0.60) EPHX2ALDH1A1PPARAF7F3
SCHEMBL28517631 0.94 ALDH1A1 (0.56) EPHX2ALDH1A1PPARAF7F3
SCHEMBL4082941 0.94 ALDH1A1 (0.56) EPHX2ALDH1A1PPARAF7F3
SCHEMBL1962827 0.91 EPHX2 (0.50) EPHX2ALDH1A1PPARAF7F3
SCHEMBL4073056 0.91 EPHX2 (0.50) EPHX2ALDH1A1PPARAF7F3
SCHEMBL4076228 0.91 EPHX2 (0.50) EPHX2ALDH1A1PPARAF7F3
SCHEMBL1962429 0.88 EPHX2 (0.75) EPHX2PPARAF7F3CYP19A1
SCHEMBL10445375 0.88 EPHX2 (0.70) EPHX2PPARAF7F3CYP19A1
SCHEMBL10445592 0.88 EPHX2 (0.70) EPHX2PPARAF7F3CYP19A1
SCHEMBL4092435 0.88 EPHX2 (0.75) EPHX2PPARAF7F3CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6121270-A N-(EPOXYALKYL)XANTHINE DERIVATIVES WHICH MODULATE CELLULAR RESPONSES TO NOXIOUS, PRO-INFLAMMATORY STIMULI CELL THERAPEUTICS, INC. (US) 2000-09-19 US disclosed
US-5866576-A COMPOUNDS THAT ACT AS DRUGS ON THE CELLULAR AND BIOCHEMICAL LEVEL TO MODULATE CELLULAR RESPONSES TO NOXIOUS, PRO-INFLAMMATORY STIMULI. CELL THERAPEUTICS, INC. (US) 1999-02-02 US disclosed