SCHEMBL8072291

SCHEMBL8072291

NC(=O)CCC(=O)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.71

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMO O15229 3/20 0.54
TSHR P16473 1/20 0.52
HSD11B1 P28845 1/20 0.47
HDAC3 O15379 2/20 0.46
HDAC4 P56524 2/20 0.46
HDAC1 Q13547 2/20 0.46
HDAC7 Q8WUI4 2/20 0.46
HDAC2 Q92769 2/20 0.46
HDAC10 Q969S8 2/20 0.46
HDAC11 Q96DB2 2/20 0.46
HDAC8 Q9BY41 2/20 0.46
HDAC6 Q9UBN7 2/20 0.46
HDAC9 Q9UKV0 2/20 0.46
HDAC5 Q9UQL6 2/20 0.46
BCAT2 O15382 1/20 0.46
SRD5A2 P31213 1/20 0.46
KDM4E B2RXH2 1/20 0.45
ALDH1A1 P00352 1/20 0.45
AGTR1 P30556 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4609783 0.91 KMO (0.53) KMOTSHRHSD11B1HDAC3HDAC4
SCHEMBL8035900 0.87 PARP1 (0.49) KMOHSD11B1HDAC3HDAC4HDAC1
SCHEMBL727064 0.83 TSHR (0.59) KMOTSHRHSD11B1SRD5A2
SCHEMBL7975027 0.82 TSHR (0.48) KMOTSHRBCAT2SRD5A2KDM4E
SCHEMBL2435064 0.81 KDM4E (0.57) KMOTSHRHSD11B1HDAC3HDAC4
SCHEMBL11392489 0.81 TSHR (0.55) KMOTSHRHSD11B1HDAC3HDAC4
SCHEMBL6998011 0.81 POLB (0.56) KMOTSHRHSD11B1HDAC3HDAC4
SCHEMBL11346061 0.80 CA1 (0.58)
SCHEMBL634176 0.79 HSD17B3 (0.55) KMOTSHRHSD11B1HDAC3HDAC4
SCHEMBL4517533 0.79 TSHR (0.53) KMOTSHRHSD11B1HDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6133302-A KYNURENINE-3-HYDROXYLASE ENZYME INHIBITORY ACTIVITY, AN ENZYME OF THE KYNURENINE (KYN) PATHWAY; COMPOUNDS SUCH AS 5-(3-(3-FLUOROPHENYL)-3-OXO-PROPYL)-1H-TETRAZOLE; FOR TREATMENT OF NEUROPATHOLOGICAL PROCESSES PHARMACIA & UPJOHN SPA (IT) 2000-10-17 US disclosed