Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KMO | O15229 | 3/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286984 | 0.84 | TSHR (0.57) | TSHRKMOHSD11B1HDAC3HDAC4 | |
| SCHEMBL6998011 | 0.82 | POLB (0.56) | TSHRKMOHSD11B1HDAC3HDAC4 | |
| SCHEMBL11392489 | 0.82 | TSHR (0.55) | TSHRKMOHSD11B1HDAC3HDAC4 | |
| SCHEMBL727064 | 0.81 | TSHR (0.59) | TSHRKMOHSD11B1SRD5A2 | |
| SCHEMBL634176 | 0.81 | HSD17B3 (0.55) | TSHRKMOHSD11B1HDAC3HDAC4 | |
| SCHEMBL9337894 | 0.80 | THRA (0.59) | TSHRKMOHDAC3HDAC4HDAC1 | |
| SCHEMBL9015106 | 0.79 | TSHR (0.61) | TSHRKMOHSD11B1HDAC3HDAC4 | |
| SCHEMBL2435064 | 0.79 | KDM4E (0.57) | TSHRKMOHSD11B1HDAC3HDAC4 | |
| SCHEMBL8072291 | 0.79 | KMO (0.54) | TSHRKMOHSD11B1HDAC3HDAC4 | |
| SCHEMBL14775644 | 0.79 | TSHR (0.52) | TSHRKMOHSD11B1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050182121-A1 | Thio semicarbazone and semicarbozone inhibitors of cysteine proteases and methods of their use | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-08-18 | — | — | US | claimed |
| US-6897240-B2 | Thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of their use | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-05-24 | — | — | US | claimed |
| US-20040014801-A1 | Thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of their use | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2004-01-22 | — | — | US | claimed |
| US-7495023-B2 | Thio semicarbazone and semicarbozone inhibitors of cysteine proteases and methods of their use | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-02-24 | — | — | US | disclosed |
| US-20050182121-A1 | Thio semicarbazone and semicarbozone inhibitors of cysteine proteases and methods of their use | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-08-18 | — | — | US | disclosed |
| US-6897240-B2 | Thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of their use | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-05-24 | — | — | US | disclosed |
| US-20040014801-A1 | Thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of their use | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2004-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014801-A1 | Thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of their use | CTSB, CTSS, CTSL | TSHR 2766/4885KMO 2015/4885HSD11B1 3054/4885 |
| US-20050182121-A1 | Thio semicarbazone and semicarbozone inhibitors of cysteine proteases and methods of their use | CTSB, CTSS, CSTB | TSHR 2544/4885KMO 1832/4885HSD11B1 2772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.