SCHEMBL8072818

SCHEMBL8072818

CSc1ccc(Oc2cccc(C(=O)NN)n2)cc1C(F)(F)F

nearest known ligand 0.48

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.48
P2RX7 Q99572 2/20 0.46
SCN9A Q15858 4/20 0.40
GRM5 P41594 1/20 0.39
KDR P35968 3/20 0.38
FLT1 P17948 2/20 0.38
FLT4 P35916 2/20 0.38
LOXL2 Q9Y4K0 3/20 0.38
LOX P28300 2/20 0.38
P2RX3 P56373 2/20 0.38
AR P10275 1/20 0.36
F10 P00742 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7110923 0.87 MAPT (0.49) MAPTSCN9ALOXL2P2RX3AR
SCHEMBL8067985 0.86 MAPT (0.51) MAPTP2RX7SCN9AGRM5KDR
SCHEMBL8070248 0.84 MAPT (0.52) MAPTP2RX7SCN9ALOXL2LOX
SCHEMBL8072764 0.83 MAPT (0.48) MAPTP2RX7SCN9AGRM5KDR
SCHEMBL8069624 0.82 MAPT (0.47) MAPTP2RX7SCN9AKDRLOXL2
SCHEMBL8065139 0.78 MAPT (0.72) MAPTP2RX7KDRFLT1FLT4
SCHEMBL3837469 0.74 SCN9A (0.58) MAPTSCN9AKDRFLT1FLT4
SCHEMBL8072815 0.72 MAPT (0.56) MAPTP2RX7KDRFLT1FLT4
SCHEMBL8068188 0.72 P2RX7 (0.53) MAPTP2RX7GRM5F10
SCHEMBL7108378 0.71 MAPT (0.49) MAPTSCN9AKDRP2RX3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6159901-A 6-phenoxy picolinic acid alkylidene hydrazide derivative, process for producing the same and herbicide using the same KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2000-12-12 US disclosed
EP-1020444-A1 6-PHENOXYPICOLINIC ACID, ALKYLIDENEHYDRAZIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND HERBICIDE KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2000-07-19 EP disclosed