Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | DPP4 | P27487 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | ACACB | O00763 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10664191 | 0.81 | ADRB3 (0.72) | SMN1; SMN2ADRB1ADRB3ADRA1ACYP1A2 | |
| SCHEMBL9468493 | 0.80 | ADRB3 (0.76) | SMN1; SMN2ADRB1ADRB3ADRA1AALDH1A1 | |
| SCHEMBL9770881 | 0.79 | SLC6A4 (0.54) | SMN1; SMN2SIGMAR1RAB9ANPC1MEN1 | |
| SCHEMBL13417829 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2SIGMAR1RAB9ANPC1ACACB | |
| SCHEMBL12326247 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9ANPC1GAAMEN1 | |
| SCHEMBL6541503 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2SIGMAR1GAAMEN1KMT2A | |
| SCHEMBL9185848 | 0.77 | SIGMAR1 (0.56) | SMN1; SMN2SIGMAR1RAB9ANPC1CYP3A4 | |
| SCHEMBL19359211 | 0.77 | SMN1; SMN2 (0.63) | SMN1; SMN2RAB9ANPC1GAAMEN1 | |
| SCHEMBL8066591 | 0.76 | SLC7A5 (0.59) | SMN1; SMN2SIGMAR1DPP4RAB9ANPC1 | |
| Ethyl Benzoate SCHEMBL11244230 | 0.76 | LMNA (0.68) | SMN1; SMN2RAB9ANPC1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028080-A | Quinolin-2-(1H)-ones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-02-22 | — | — | US | disclosed |
| EP-0885196-A1 | CHINOLINE-2-(1H)-ONES | MERCK PATENT GmbH (DE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997026244-A1 | CHINOLINE-2-(1H)-ONES | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-07-24 | — | — | WO | disclosed |